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Coombs test (DAT/IAT)

Antibodies attacking red cells.

General health information, not a diagnosis. In an emergency, call 102. Always consult a qualified health professional.

SmartAnswer by DigiNepal SI

The Coombs test, also known as DAT or IAT, is used to detect antibodies that are attacking red blood cells. This test is typically performed when there's suspicion of haemolytic anaemia, particularly in pregnant women who are Rh negative, or in newborns with jaundice. The test involves preparing the blood sample, which can be done without fasting. The results, high or positive, indicate the presence of antibodies, while low or negative results suggest the absence of antibodies. The Coombs test is crucial for diagnosing specific conditions and guiding appropriate treatment. However, the interpretation of the results must be done by a qualified health professional.

Sources: SI health summary (own words); MedlinePlus Lab Tests and CDC as references

Why it is done

Haemolytic anaemia, pregnancy (Rh negative), newborn jaundice.

Preparation

No fasting needed. Laboratory-specific; see the reference range on your report. High or positive may mean: Antibodies present. Low or negative may mean: Not detected. General information, not a diagnosis. Results must be interpreted by a qualified health worker.

⚠️ Reference ranges vary by lab, age and sex — always use the range printed on your own report.

Consult a doctor to interpret results — a single test does not make a diagnosis.

Where to get this near you

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Common questions

Why is Coombs test (DAT/IAT) done?
Haemolytic anaemia, pregnancy (Rh negative), newborn jaundice.

Do I need to prepare or fast for Coombs test (DAT/IAT)?
No fasting needed. Laboratory-specific; see the reference range on your report. High or positive may mean: Antibodies present. Low or negative may mean: Not detected. General information, not a diagnosis. Results must be interpreted by a qualified health worker.

SI text CC BY 4.0; decoder reference data (cited per range); LOINC codes free with attribution (notice included).

Sources: SI health summary (own words); MedlinePlus Lab Tests and CDC as references

Emergency — call📞 102