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Ustekinumab

WHO Essential Medicine EML section: Medicines affecting skin differentiation and proliferation

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SmartAnswer by DigiNepal SI

Ustekinumab is used for: Ustekinumab-aekn is a human interleukin-12 and -23 antagonist indicated for the treatment of: Adult patients with: moderate to severe plaque psoriasis (PsO) who are candidates for phototherapy or systemic therapy. active psoriatic arthritis (PsA). moderately to severely active Crohn’s disease (CD). moderately to severely active ulcerative colitis. Common side effects include: The following serious adverse reactions are discussed elsewhere in the label: Infections Malignancies Serious Hypersensitivity Reactions Posterior Reversible Encephalopathy Syndrome (PRES) Noninfectious Pneumonia Most common adverse reactions are: Psoriasis and Psoriatic Arthritis (≥3%): nasopharyngitis, upper respiratory tract infection,.... What it is used for: Ustekinumab-aekn is a human interleukin-12 and -23 antagonist indicated for the treatment of: Adult patients with: moderate to severe plaque psoriasis (PsO) who are candidates for phototherapy or systemic therapy. active psoriatic arthritis (PsA). moderately to severely active Crohn’s disease (CD). moderately to severely active ulcerative colitis. generated by SI from cited sources · general information, not a diagnosis · consult a health professional

Sources: FDA SPL label (openFDA/DailyMed); RxNorm (NLM) · Reference · Reference · Reference

Brand names

Nepal brand names not included: no licence-safe source.

What it is used for

Ustekinumab-aekn is a human interleukin-12 and -23 antagonist indicated for the treatment of: Adult patients with: moderate to severe plaque psoriasis (PsO) who are candidates for phototherapy or systemic therapy. active psoriatic arthritis (PsA). moderately to severely active Crohn’s disease (CD). moderately to severely active ulcerative colitis.

How it works

Ustekinumab products are human IgG1κ monoclonal antibodies that bind with specificity to the p40 protein subunit used by both the IL-12 and IL-23 cytokines.

Common side effects

The following serious adverse reactions are discussed elsewhere in the label: Infections Malignancies Serious Hypersensitivity Reactions Posterior Reversible Encephalopathy Syndrome (PRES) Noninfectious Pneumonia Most common adverse reactions are: Psoriasis and Psoriatic Arthritis (≥3%): nasopharyngitis, upper respiratory tract infection,...

Do not use if (contraindications)

Ustekinumab-aekn is contraindicated in patients with clinically significant hypersensitivity to ustekinumab products or to any of the excipients in Ustekinumab-aekn. Clinically significant hypersensitivity to ustekinumab products or to any of the excipients in Ustekinumab-aekn.

Pregnancy & breastfeeding

Pregnancy (label summary): Risk Summary Available data from the Organization of Teratology Information Specialists (OTIS)/Mother To Baby Pregnancy Registry, published literature and pharmacovigilance in pregnant women have not identified an ustekinumab-associated risk of major birth defects, miscarriage or other adverse...

Overdose or poisoning

For a suspected overdose or poisoning, call 102 now and go to the nearest emergency hospital.

Call 102

Common questions

What is Ustekinumab used for?
Ustekinumab-aekn is a human interleukin-12 and -23 antagonist indicated for the treatment of: Adult patients with: moderate to severe plaque psoriasis (PsO) who are candidates for phototherapy or systemic therapy. active psoriatic arthritis (PsA). moderately to severely active Crohn’s disease (CD).

How does Ustekinumab work?
Ustekinumab products are human IgG1κ monoclonal antibodies that bind with specificity to the p40 protein subunit used by both the IL-12 and IL-23 cytokines.

What are the side effects of Ustekinumab?
The following serious adverse reactions are discussed elsewhere in the label: Infections Malignancies Serious Hypersensitivity Reactions Posterior Reversible Encephalopathy Syndrome (PRES) Noninfectious Pneumonia Most common adverse reactions are: Psoriasis and Psoriatic Arthritis (≥3%): nasopharyngitis, upper...

Who should not take Ustekinumab?
Ustekinumab-aekn is contraindicated in patients with clinically significant hypersensitivity to ustekinumab products or to any of the excipients in Ustekinumab-aekn. Clinically significant hypersensitivity to ustekinumab products or to any of the excipients in Ustekinumab-aekn.

Can I take Ustekinumab in pregnancy or while breastfeeding?
Pregnancy (label summary): Risk Summary Available data from the Organization of Teratology Information Specialists (OTIS)/Mother To Baby Pregnancy Registry, published literature and pharmacovigilance in pregnant women have not identified an ustekinumab-associated risk of major birth defects, miscarriage or other...

What is the dose of Ustekinumab?
Not provided here. Ask a doctor or pharmacist.

What is Ustekinumab?
Ustekinumab is used for: Ustekinumab-aekn is a human interleukin-12 and -23 antagonist indicated for the treatment of: Adult patients with: moderate to severe plaque psoriasis (PsO) who are candidates for phototherapy or systemic therapy. active psoriatic arthritis (PsA). moderately to severely active Crohn’s diseas…

Sources: FDA SPL label (openFDA/DailyMed); RxNorm (NLM) · Reference · Reference · Reference

US FDA DailyMed; NLM RxNorm

Emergency — call102