Methotrexate

ब्रान्ड नाम

Nepal brand names not included: no licence-safe source.

What it is used for

Methotrexate tablets are a diydrofolate reductase inhibitor indicated for the: • Treatment of adults and pediatric patients with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance regimen • Treatment of adults with mycosis fungoides • Treatment of adults with relapsed or refractory non-Hodgkin lymphoma as part of a metronomic combination regimen • Treatment of adults with...

How it works

Methotrexate inhibits dihydrofolic acid reductase. Dihydrofolates must be reduced to tetrahydrofolates by this enzyme before they can be utilized as carriers of one-carbon groups in the synthesis of purine nucleotides and thymidylate.

Common side effects

The following clinically significant adverse reactions are described elsewhere in the labeling: Hypersensitivity Reactions Myelosuppression Gastrointestinal Toxicity Hepatotoxicity Pulmonary Toxicity Dermatologic Reactions Renal Toxicity Serious Infections Neurotoxicity Secondary Malignancies Tumor Lysis Syndrome Increased Risk of Adverse...

Do not use if (contraindications)

Methotrexate tablets are contraindicated in: • Pregnant women receiving methotrexate tablets for treatment of non-neoplastic diseases. • Patients with a history of severe hypersensitivity reactions, including anaphylaxis, to methotrexate..

Pregnancy & breastfeeding

Pregnancy (label summary): Risk Summary Methotrexate is contraindicated in pregnant women with non-neoplastic diseases. Based on published reports and its mechanism of action, methotrexate can cause embryo-fetal toxicity and fetal death when administered to a pregnant woman.

सामान्य प्रश्न

What is Methotrexate used for?
Methotrexate tablets are a diydrofolate reductase inhibitor indicated for the: • Treatment of adults and pediatric patients with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance regimen • Treatment of adults with mycosis fungoides • Treatment of adults with relapsed or refractory...

How does Methotrexate work?
Methotrexate inhibits dihydrofolic acid reductase. Dihydrofolates must be reduced to tetrahydrofolates by this enzyme before they can be utilized as carriers of one-carbon groups in the synthesis of purine nucleotides and thymidylate.

What are the side effects of Methotrexate?
The following clinically significant adverse reactions are described elsewhere in the labeling: Hypersensitivity Reactions Myelosuppression Gastrointestinal Toxicity Hepatotoxicity Pulmonary Toxicity Dermatologic Reactions Renal Toxicity Serious Infections Neurotoxicity Secondary Malignancies Tumor Lysis Syndrome...

Who should not take Methotrexate?
Methotrexate tablets are contraindicated in: • Pregnant women receiving methotrexate tablets for treatment of non-neoplastic diseases. • Patients with a history of severe hypersensitivity reactions, including anaphylaxis, to methotrexate..

Does Methotrexate have a boxed warning?
EMBRYO-FETAL TOXICITY, HYPERSENSITIVITY REACTIONS, SEVERE ADVERSE REACTIONS, and RISK OF MEDICATION ERRORS • Methotrexate tablets can cause embryo-fetal toxicity, including fetal death. For non-neoplastic diseases, methotrexate tablets are contraindicated in pregnancy.

Can I take Methotrexate in pregnancy or while breastfeeding?
Pregnancy (label summary): Risk Summary Methotrexate is contraindicated in pregnant women with non-neoplastic diseases. Based on published reports and its mechanism of action, methotrexate can cause embryo-fetal toxicity and fetal death when administered to a pregnant woman.

What is the dose of Methotrexate?
Not provided here. Ask a doctor or pharmacist.

Methotrexate के हो?
Methotrexate is used for: Methotrexate tablets are a diydrofolate reductase inhibitor indicated for the: • Treatment of adults and pediatric patients with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance regimen • Treatment of adults with mycosis fungoides • Treatment of adults wi…