Osmotic Diuretic
WHO Essential Medicine EML section: Diuretics
This is information only, not a prescription. Talk to a doctor or pharmacist before taking any medicine. For an overdose or poisoning, call 102.
Mannitol is an osmotic diuretic used to reduce intracranial pressure and treat cerebral edema. It works by being a small solute that stays mostly in the extracellular space, exerting an osmotic diuretic effect when administered intravenously. Common side effects include the following: voluntary reports or clinical studies have identified adverse reactions such as headache, dizziness, and nausea. Mannitol is contraindicated in patients with known hypersensitivity to mannitol, anuria, severe hypovolemia, pre-existing severe pulmonary vascular congestion or pulmonary edema, active intracranial bleeding except during craniotomy, and known hypersensitivity to mannitol. Pregnant women should not use it due to lack of a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.
Sources: FDA SPL label (openFDA/DailyMed); RxNorm (NLM) · Reference · Reference · Reference
Nepal brand names not included: no licence-safe source.
is indicated for: • The reduction of intracranial pressure and treatment of cerebral edema; • The reduction of elevated intraocular pressure. OSMITROL is an osmotic diuretic, indicated for the reduction of: • intracranial pressure and treatment of cerebral edema. • elevated intraocular pressure.
Mannitol, when administered intravenously, exerts its osmotic diuretic effect as a solute of relatively small molecular size being largely confined to the extracellular space.
The following adverse reactions from voluntary reports or clinical studies have been reported with OSMITROL. Because many of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
is contraindicated in patients with: • Known hypersensitivity to mannitol • Anuria • Severe hypovolemia • Pre-existing severe pulmonary vascular congestion or pulmonary edema • Active intracranial bleeding except during craniotomy • Known hypersensitivity to mannitol. ( 4, 5.1 ) • Anuria.
Pregnancy (label summary): Risk Summary The available case report data with mannitol over decades of use have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.
For a suspected overdose or poisoning, call 102 now and go to the nearest emergency hospital.
Call 102What is Mannitol used for?
is indicated for: • The reduction of intracranial pressure and treatment of cerebral edema; • The reduction of elevated intraocular pressure. OSMITROL is an osmotic diuretic, indicated for the reduction of: • intracranial pressure and treatment of cerebral edema. • elevated intraocular pressure.
How does Mannitol work?
Mannitol, when administered intravenously, exerts its osmotic diuretic effect as a solute of relatively small molecular size being largely confined to the extracellular space.
What are the side effects of Mannitol?
The following adverse reactions from voluntary reports or clinical studies have been reported with OSMITROL. Because many of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Who should not take Mannitol?
is contraindicated in patients with: • Known hypersensitivity to mannitol • Anuria • Severe hypovolemia • Pre-existing severe pulmonary vascular congestion or pulmonary edema • Active intracranial bleeding except during craniotomy • Known hypersensitivity to mannitol. ( 4, 5.1 ) • Anuria.
Can I take Mannitol in pregnancy or while breastfeeding?
Pregnancy (label summary): Risk Summary The available case report data with mannitol over decades of use have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.
What is the dose of Mannitol?
Not provided here. Ask a doctor or pharmacist.
What is Mannitol?
Mannitol is used for: is indicated for: • The reduction of intracranial pressure and treatment of cerebral edema; • The reduction of elevated intraocular pressure. It belongs to the class: Osmotic Diuretic. Common side effects include: The following adverse reactions from voluntary reports or clinical studies have b…
Sources: FDA SPL label (openFDA/DailyMed); RxNorm (NLM) · Reference · Reference · Reference
US FDA DailyMed; NLM RxNorm