WHO Essential Medicine EML section: Opioid analgesics
This is information only, not a prescription. Talk to a doctor or pharmacist before taking any medicine. For an overdose or poisoning, call 102.
SERIOUS AND LIFE-THREATENING RISKS FROM USE OF CODEINE SULFATE TABLETS Addiction, Abuse, and Misuse Because the use of Codeine Sulfate Tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient’s risk prior to prescribing and reassess all patients...
Codeine is an opioid medication used to manage mild to moderate pain. It is indicated for use when other pain treatments are not effective. Common side effects include drowsiness, constipation, and nausea. Serious adverse reactions include life-threatening respiratory depression, interactions with benzodiazepines, and neonatal opioid withdrawal syndrome. Codeine is contraindicated for children under 12 years and post-operative management in children under 18 following tonsillectomy and adenoidectomy. Always consult a healthcare professional for medical advice.
Sources: FDA SPL label (openFDA/DailyMed); RxNorm (NLM) · Reference · Reference · Reference
Nepal brand names not included: no licence-safe source.
Codeine Sulfate Tablets are indicated for the management of mild to moderate pain, where treatment with an opioid is appropriate and for which alternative treatments are inadequate. Codeine Sulfate Tablets are an opioid agonist, indicated for the management of mild to moderate pain, where treatment with an opioid is appropriate and for which alternative treatments are inadequate. ( 1, 5.1 )
Codeine sulfate is an opioid agonist relatively selective for the mu-opioid receptor, but with a much weaker affinity than morphine. The analgesic properties of codeine have been speculated to come from its conversion to morphine, although the exact mechanism of analgesic action remains unknown.
The following serious adverse reactions are described, or described in greater detail, in other sections: • Addiction, Abuse, and Misuse • Life-Threatening Respiratory Depression • Interactions with Benzodiazepines and Other CNS Depressants • Neonatal Opioid Withdrawal Syndrome • Ultra-Rapid Metabolism of Codeine and Other Risk Factors for...
Codeine Sulfate Tablets are contraindicated for: • All children younger than 12 years of age. • Post-operative management in children younger than 18 years of age following tonsillectomy and/or adenoidectomy.
Pregnancy (label summary): Risk Summary: Use of opioid analgesics for an extended period of time during pregnancy may cause neonatal opioid withdrawal syndrome. Available data with Codeine Sulfate Tablets are insufficient to inform a drug-associated risk for major birth defects and miscarriage.
For a suspected overdose or poisoning, call 102 now and go to the nearest emergency hospital.
Call 102What is Codeine used for?
Codeine Sulfate Tablets are indicated for the management of mild to moderate pain, where treatment with an opioid is appropriate and for which alternative treatments are inadequate.
How does Codeine work?
Codeine sulfate is an opioid agonist relatively selective for the mu-opioid receptor, but with a much weaker affinity than morphine. The analgesic properties of codeine have been speculated to come from its conversion to morphine, although the exact mechanism of analgesic action remains unknown.
What are the side effects of Codeine?
The following serious adverse reactions are described, or described in greater detail, in other sections: • Addiction, Abuse, and Misuse • Life-Threatening Respiratory Depression • Interactions with Benzodiazepines and Other CNS Depressants • Neonatal Opioid Withdrawal Syndrome • Ultra-Rapid Metabolism of Codeine and...
Who should not take Codeine?
Codeine Sulfate Tablets are contraindicated for: • All children younger than 12 years of age. • Post-operative management in children younger than 18 years of age following tonsillectomy and/or adenoidectomy.
Does Codeine have a boxed warning?
SERIOUS AND LIFE-THREATENING RISKS FROM USE OF CODEINE SULFATE TABLETS Addiction, Abuse, and Misuse Because the use of Codeine Sulfate Tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient’s risk prior to prescribing and...
Can I take Codeine in pregnancy or while breastfeeding?
Pregnancy (label summary): Risk Summary: Use of opioid analgesics for an extended period of time during pregnancy may cause neonatal opioid withdrawal syndrome. Available data with Codeine Sulfate Tablets are insufficient to inform a drug-associated risk for major birth defects and miscarriage.
What is the dose of Codeine?
Not provided here. Ask a doctor or pharmacist.
What is Codeine?
Codeine is used for: Codeine Sulfate Tablets are indicated for the management of mild to moderate pain, where treatment with an opioid is appropriate and for which alternative treatments are inadequate. Common side effects include: The following serious adverse reactions are described, or described in greater detail…
Sources: FDA SPL label (openFDA/DailyMed); RxNorm (NLM) · Reference · Reference · Reference
US FDA DailyMed; NLM RxNorm