💊 Spironolactone (स्पाइरोनोल्याक्टोन)

SmartAnswer by DigiNepal SI

How it works: Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Do not use if: Spironolactone tablets are contraindicated in the patients with: • Hyperkalemia • Addison's disease • Concomitant use of eplerenone Spironolactone tablets are contraindicated in patients with: • Hyperkalemia • Addison's disease • Concomitant use of eplerenone Pregnancy (label summary): Risk Summary Based on mechanism of action and findings in animal studies, spironolactone may affect sex differentiation of the male during embryogenesis (see Data). Rat embryofetal studies report feminization of male fetuses and endocrine dysfunction in females exposed to spironolactone in utero. General information only, not medical advice and not a prescription. No doses are given. Always consult a doctor or pharmacist before starting, stopping or changing any medicine, especially in pregnancy, breastfeeding, children, older age or with other medicines. generated by SI from cited sources · general information, not a diagnosis · consult a health professional

Sources: FDA SPL label (openFDA/DailyMed); RxNorm (NLM)

How it works

Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Do not use if: Spironolactone tablets are contraindicated in the patients with: • Hyperkalemia • Addison's disease • Concomitant use of eplerenone Spironolactone tablets are contraindicated in patients with: • Hyperkalemia • Addison's disease • Concomitant use of eplerenone Pregnancy (label summary): Risk Summary Based on mechanism of action and findings in animal studies, spironolactone may affect sex differentiation of the male during embryogenesis (see Data). Rat embryofetal studies report feminization of male fetuses and endocrine dysfunction in females exposed to spironolactone in utero. General information only, not medical advice and not a prescription. No doses are given. Always consult a doctor or pharmacist before starting, stopping or changing any medicine, especially in pregnancy, breastfeeding, children, older age or with other medicines.