💊 Benzathine Penicillin G (बेन्जाथिन पेनिसिलिन)

SmartAnswer by DigiNepal SI

How it works: Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable. Boxed warning: NOT FOR INTRAVENOUS USE. DO NOT INJECT INTRAVENOUSLY OR ADMIX WITH OTHER INTRAVENOUS SOLUTIONS. THERE HAVE BEEN REPORTS OF INADVERTENT INTRAVENOUS ADMINISTRATION OF PENICILLIN G BENZATHINE WHICH HAS BEEN ASSOCIATED WITH CARDIORESPIRATORY ARREST AND DEATH. WARNING NOT FOR INTRAVENOUS USE. Do not use if: A history of a previous hypersensitivity reaction to any of the penicillins is a contraindication. generated by SI from cited sources · general information, not a diagnosis · consult a health professional

Sources: FDA SPL label (openFDA/DailyMed); RxNorm (NLM)

How it works

Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable. Boxed warning: NOT FOR INTRAVENOUS USE. DO NOT INJECT INTRAVENOUSLY OR ADMIX WITH OTHER INTRAVENOUS SOLUTIONS. THERE HAVE BEEN REPORTS OF INADVERTENT INTRAVENOUS ADMINISTRATION OF PENICILLIN G BENZATHINE WHICH HAS BEEN ASSOCIATED WITH CARDIORESPIRATORY ARREST AND DEATH. WARNING NOT FOR INTRAVENOUS USE. Do not use if: A history of a previous hypersensitivity reaction to any of the penicillins is a contraindication.

Common side effects

As with other penicillins, untoward reactions of the sensitivity phenomena are likely to occur, particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with a history of allergy, asthma, hay fever, or urticaria. As with other treatments for syphilis, the Jarisch-Herxheimer reaction has been reported. Pregnancy (label summary): Teratogenic effects Pregnancy Reproduction studies performed in the mouse, rat, and rabbit have revealed no evidence of impaired fertility or harm to the fetus due to penicillin G. Breastfeeding (label summary): Nursing Mothers Soluble penicillin G (the hydrolysate of penicillin G benzathine) is excreted in breast milk. Caution should be exercised when penicillin G benzathine is administered to a nursing woman. General information only, not medical advice and not a prescription. No doses are given. Always consult a doctor or pharmacist before starting, stopping or changing any medicine, especially in pregnancy, breastfeeding, children, older age or with other medicines.